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UNC5B/UNC5H2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981412
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50-198-1412 100 μL
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Catalog No. 50-198-1412 Supplier Bioss Supplier No. BS11492R
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Description

Rabbit Polyclonal Antibody

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

Specifications

Antigen UNC5B/UNC5H2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene UNC5B
Gene Accession No. Q8IZJ1
Gene Alias 6330415E02Rik; A630020F16; C. elegans; D10Bwg0792e; Netrin receptor UNC5B; P53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; Protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 homolog 2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; Unc5b; UNC5H2; UNQ1883/PRO4326
Gene Symbols UNC5B
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human UNC5B.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 219699
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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