RPSA, Mouse, Clone: 33, Abnova™

Mouse monoclonal antibody raised against full-length recombinant RPSA.

Supplier:  Abnova Corporation MAB9943

Catalog No. 89-113-901

Description

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as nonintegrin laminin-binding proteins. This gene encodes a high-affinity, nonintegrin family, laminin receptor 1. This receptor has been variously called 67kDa laminin receptor, 37kDa laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Specifications

• Antigen: RPSA
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Western blot (1:1000) The optimal working dilution should be determined by the end user.
• Gene: RPSA
• Gene Alias: 37LRP/67LR/LAMBR/LAMR1/LRP/p40
• Host Species: Mouse
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 3921
• Target Species: Human
• Form: Liquid

• Applications: ELISA, Western Blot
• Clone: 33
• Description: Mouse monoclonal antibody raised against full length recombinant RPSA.
• Formulation: In Citrate-Tris-HCl buffer, pH 7.0 (0.02% Proclin 300)
• Gene Accession No.: NM_002295.4
• Gene Symbols: RPSA
• Immunogen: Recombinant protein corresponding to full length human RPSA.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: It can expression in HeLa whole cell lysate.
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2a