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MilliporeSigma™ Mouse anti-pan-AMPA receptor (GluR1-4), Clone: 2D8,

Catalog No. MABN832MI Shop All MilliporeSigma Products
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MABN832MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects pan-AMPA receptor (GluR1-4) clone: 2D8 in Human, Rat samples, and it is validated for Electron Microscopy, ELISA, Enzyme Immunoassay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting

Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells. Upon ligand stimulation, ionotropic glutamate receptors (iGluRs) form non-selective cation channels, while metabotropic glutamate receptors (mGluRs) indirectly activate ion channels via G protein-mediated signaling. AMPA receptors are iGluRs and are also known as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, AMPARs, or quisqualate receptors. AMPARs are composed of four types of subunits, GluR1/GluA1 (UniProt P42261) is encoded by GRIA1, GluR2/GluA2 (UniProt P42262) by GRIA2, GluR3/GluA3 (UniProt P42263) by GRIA3, and GluR4/GluA4 (UniProt P48058) by GRIA4 gene in human. AMPARs are tetrameric in nature, consisting of two sets of homodimers, most often a set of GluR2 dimer is coupled with a set of GluR1, GluR3 or GluR4 homodimer. Anti-pan-AMPA receptor (GluR1-4), clone 2D8, reacts with all four AMPA receptor subunits.
TRUSTED_SUSTAINABILITY

Specifications

Antigen pan-AMPA receptor (GluR1-4)
Applications Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 2D8
Formulation Purified mouse monoclonal IgG2bκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P42261; P42262; P42263; P48058
Gene Symbols GRIA1; GLUH1; GLUR1
Host Species Mouse
Immunogen Fusion protein coding for the extracellular domain of AMPA Glutamate receptor 1-4 corresponding to human pan-AMPA receptor (GluR1-4).
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_000818; NP_000817; NP_000819; NP_000820
Target Species Human, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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