Invitrogen™ JAM-A (CD321) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120157

Catalog No. PIPA5120157

Description

Positive test controls include: HepG2, SKOV3, Mouse lung, Rat lung. The target is usually found in the following locations: Cell junction, Cell membrane, Single-pass type I membrane protein, tight junction. Immunogen sequence: SVTVHSSEPE VRIPENNPVK LSCAYSGFSS PRVEWKFDQG DTTRLVCYNN KITASYEDRV TFLPTGITFK SVTREDTGTY TCMVSEEGGN SYGEVKVKLI VLVPPSKPTV NIPSSATIGN RAVLTCSEQD GSPPSEYTWF KDGIVMPTNP KSTRAFSNSS YVLNPTTGEL VFDPLSASDT GEYSCEARNG YGTPMTSNAV RMEAVERNVG V.

CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.

Specifications

• Antigen: JAM-A (CD321)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: F11r
• Gene Alias: 9130004G24; AA638916; BV11 antigen; CD321; ESTM33; F11 R; F11 receptor; F11 receptor/F11R; F11R; JAM; JAM1; JAM-1; JAMA; JAM-A; Jcam; Jcam1; junction cell adhesion molecule A; junction cell adhesion molecule1; junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; Ly106; PAM-1; Platelet adhesion molecule 1; platelet F11 receptor; UNQ264/PRO301
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116479, 16456, 50848
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.64 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O88792, Q9JHY1, Q9Y624
• Gene Symbols: F11r
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 28-238 of human JAM-A/CD321/F11R (NP_0586421).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG