Invitrogen™ CEP164 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106345

Catalog No. PIPA5106345

Description

Antibody detects endogenous levels of total CEP164.

CEP164 was initially identified as a centrosomal protein, but other studies have indicated that it also plays a role in the formation of primary cilia, the microtubule-based sensory antennae projecting from the surface of many eukaryotic cells as well as in DNA damage response acting as a mediator protein. CEP164 interacts with both ATR and ATM, proteins that trigger a number of cellular responses including the initiation of DNA damaged-induced cell cycle checkpoints. It is phosphorylated upon replication stress, ultraviolet (UV) radiation, and ionizing radiation silencing of CEP164 significantly reduces the DNA damage-induced phosphorylation of several proteins in the DNA damage-activated signaling cascade and compromises cell survival after UV damage. At least two isoforms of CEP164 are known to exist.

Specifications

• Antigen: CEP164
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CEP164
• Gene Alias: AI450905; BC027092; ce164; centrosomal protein 164; centrosomal protein 164kDa; centrosomal protein of 164 kDa; Cep 164; CEP164; D030051D21; KIAA1052; mKIAA1052; NPHP15; RGD1560988; RGD1561243
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22897, 363055, 489389
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9UPV0
• Gene Symbols: CEP164
• Immunogen: A synthesized peptide derived from human CEP164(Accession Q9UPV0), corresponding to amino acid residues Q1333-G1383.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Canine
• Product Type: Antibody
• Isotype: IgG