Invitrogen™ CD49a (Integrin alpha 1) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579525

Catalog No. PIPA579525

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell. IHC: human esophageal squamous carcinoma tissue, human lung adenocarcinoma tissue, human placenta tissue, human liver cancer tissue.

Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.

Specifications

• Antigen: CD49a (Integrin alpha 1)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Itga1
• Gene Alias: CD49 antigen-like family member A; CD49a; E130012M19Rik; integrin alpha 1; integrin alpha-1; integrin subunit alpha 1; integrin, alpha 1; Itga1; Laminin and collagen receptor; very late activation protein 1; Vla1; VLA-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 109700, 25118, 3672
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: P18614, P56199, Q3V3R4
• Gene Symbols: Itga1
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1 (1121-1134aa SNQKRELAIQISKD).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov