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Alkaline Phosphatase/ALPP Antibody (GM022), Alexa Fluor™ 594, Novus Biologicals™
SDP

Catalog No. NP247992A94 Shop All R&D Systems Products
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NP247992A94 0.1 mL
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Catalog No. NP247992A94 Supplier Novus Biologicals Supplier No. NBP247992AF594
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Description

Mouse Monoclonal Antibody

Alkaline Phosphatase/ALPP Monoclonal specifically detects Alkaline Phosphatase/ALPP in Human samples. It is validated for Western Blot.

Specifications

Antigen Alkaline Phosphatase/ALPP
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone GM022
Conjugate Alexa Fluor 594
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias Alkaline phosphatase Regan isozyme, alkaline phosphatase, placental, alkaline phosphatase, placental (Regan isozyme), alkaline phosphatase, placental type, alkaline phosphomonoesterase, ALP, EC 3.1.3.1, FLJ61142, glycerophosphatase, PALP, Placental alkaline phosphatase 1, PLAP, PLAP-1, Regan isozyme
Gene Symbols ALPP
Host Species Mouse
Immunogen Recombinant human Alkaline Phosphatase/ALPP protein (Uniprot: P05187)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cancer, Embryonic Stem Cell Markers, Ovarian Carcinoma Cell Markers, Phospho Specific, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 250.0
Test Specificity Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2b κ
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